Further evidence for the genetic association between CACNA1I and schizophrenia.

ABSTRACT:

Background

Recent large-scale genome-wide association studies (GWAS) have showed that the neuronal calcium signaling has pivotal roles in schizophrenia (SCZ) in populations of European of ancestry. However, it is not known if calcium signaling pathway genes are also associated with SCZ in Han Chinese population.

Methods

Here we investigated the association between genetic variants in three calcium signaling pathway genes (CACNB2, CACNA1C and CACNA1I) and SCZ in 1615 SCZ cases and 1597 controls.

Results

A single nucleotide polymorphism (SNP) (rs4522708) in CACNA1I is significantly associated with SCZ in our Chinese sample (OR_{A allele} = 1.19, corrected P = 0.042), suggesting that CACNA1I may also be a risk gene for SC

SUBMITTER: Xie Y 

PROVIDER: S-EPMC5749009 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature