Genetics and clinical response to warfarin and edoxaban in patients with venous thromboembolism.

ABSTRACT:

Objective

The aim of this study was to investigate whether genetic variants can identify patients with venous thromboembolism (VTE) at an increased risk of bleeding with warfarin.

Methods

Hokusai-venous thromboembolism (Hokusai VTE), a randomised, multinational, double-blind, non-inferiority trial, evaluated the safety and efficacy of edoxaban versus warfarin in patients with VTE initially treated with heparin. In this subanalysis of Hokusai VTE, patients genotyped for variants in CYP2C9 and VKORC1 genes were divided into three warfarin sensitivity types (normal, sensitive and highly sensitive) based on their genotypes. An exploratory analysis was also conducted comparing normal responders to pooled sensitive responders (ie, sensitive and highly sensitive respo

SUBMITTER: Vandell AG 

PROVIDER: S-EPMC5749368 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature