A policy model of cardiovascular disease in moderate-to-advanced chronic kidney disease.

ABSTRACT:

Objective

To present a long-term policy model of cardiovascular disease (CVD) in moderate-to-advanced chronic kidney disease (CKD).

Methods

A Markov model with transitions between CKD stages (3B, 4, 5, on dialysis, with kidney transplant) and cardiovascular events (major atherosclerotic events, haemorrhagic stroke, vascular death) was developed with individualised CKD and CVD risks estimated using the 5 years' follow-up data of the 9270 patients with moderate-to-severe CKD in the Study of Heart and Renal Protection (SHARP) and multivariate parametric survival analysis. The model was assessed in three further CKD cohorts and compared with currently used risk scores.

Results

Higher age, previous cardiovascular events and advanced CKD were the main contributors to increa

SUBMITTER: Schlackow I 

PROVIDER: S-EPMC5749372 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature