Characterization of Prostate Cancer in a Functional Eunuch.

ABSTRACT:

Background

Eunuchs rarely, if ever, develop prostate cancer (CaP). This article reports on a 62-year-old functional eunuch from prepubertal mumps orchitis who developed clinically localized CaP.

Methods

Serum and CaP and benign prostate tissue androgen levels were measured using a validated liquid chromatography-tandem mass spectrometry assay. The assay measures testosterone; dihydrotestosterone (DHT); the adrenal androgens, androstenedione and dehydroepiandrosterone; and the androgen metabolites, androsterone and androstanedione. Gene and protein expression levels of androgen metabolism enzymes, and androgen receptor and androgen-regulated genes were measured using quantitative reverse-transcription polymerase chain reaction and immunohistochemistry, respectively.

Result

SUBMITTER: Stocking JJ 

PROVIDER: S-EPMC5749417 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature