Frailty and maximal exercise capacity in adult lung transplant candidates.

ABSTRACT:

Background

Frail lung transplant candidates are more likely to be delisted or die without receiving a transplant. Further knowledge of what frailty represents in this population will assist in developing interventions to prevent frailty from developing. We set out to determine whether frail lung transplant candidates have reduced exercise capacity independent of disease severity and diagnosis.

Methods

Sixty-eight adult lung transplant candidates underwent cardiopulmonary exercise testing (CPET) and a frailty assessment (Fried's Frailty Phenotype (FFP)). Primary outcomes were peak workload and peak aerobic capacity (V˙O₂). We used linear regression to adjust for age, gender, diagnosis, and lung allocation score (LAS).

Results

The mean ± SD age was 57 ± 11 ye

SUBMITTER: Layton AM 

PROVIDER: S-EPMC5749422 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature