Dataset Information

Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil.

ABSTRACT: Yellow fever virus RNA is usually detected in blood of infected humans. We detected virus RNA in urine and semen samples from a convalescent patient. A complete virus genome was sequenced for an isolate from a urine sample. This virus had a South American I genotype and unique synapomorphic changes.

SUBMITTER: Barbosa CM

PROVIDER: S-EPMC5749440 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil.

Barbosa Carla M CM Di Paola Nicholas N Cunha Marielton P MP Rodrigues-Jesus Mônica J MJ Araujo Danielle B DB Silveira Vanessa B VB Leal Fabyano B FB Mesquita Flávio S FS Botosso Viviane F VF Zanotto Paolo M A PMA Durigon Edison L EL Silva Marcos V MV Oliveira Danielle B L DBL

Emerging infectious diseases 20180117 1

Yellow fever virus RNA is usually detected in blood of infected humans. We detected virus RNA in urine and semen samples from a convalescent patient. A complete virus genome was sequenced for an isolate from a urine sample. This virus had a South American I genotype and unique synapomorphic changes. ...[more]

PMID: 29058663

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Project description:The recent reemergence of yellow fever virus (YFV) in Brazil has raised serious concerns due to the rapid dissemination of the virus in the southeastern region. To better understand YFV genetic diversity and dynamics during the recent outbreak in southeastern Brazil, we generated 18 complete and nearly complete genomes from the peak of the epidemic curve from nonhuman primates (NHPs) and human infected cases across the Espírito Santo and Rio de Janeiro states. Genomic sequencing of 18 YFV genomes revealed the estimated timing, source, and likely routes of yellow fever virus transmission and dispersion during one of the largest outbreaks ever registered in Brazil. We showed that during the recent epidemic, YFV was reintroduced from Minas Gerais to the Espírito Santo and Rio de Janeiro states multiple times between 2016 and 2019. The analysis of data from portable sequencing could identify the corridor of spread of YFV. These findings reinforce the idea that continued genomic surveillance strategies can provide information on virus genetic diversity and transmission dynamics that might assist in understanding arbovirus epidemics.IMPORTANCE Arbovirus infections in Brazil, including yellow fever, dengue, zika, and chikungunya, result in considerable morbidity and mortality and are pressing public health concerns. However, our understanding of these outbreaks is hampered by the limited availability of genomic data. In this study, we investigated the genetic diversity and spatial distribution of YFV during the current outbreak by analyzing genomic data from areas in southeastern Brazil not covered by other previous studies. To gain insights into the routes of YFV introduction and dispersion, we tracked the virus by sequencing YFV genomes sampled from nonhuman primates and infected patients from the southeastern region. Our study provides an understanding of how YFV initiates transmission in new Brazilian regions and illustrates that genomics in the field can augment traditional approaches to infectious disease surveillance and control.

Dataset Information

Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil.

Publications

Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil.

Similar Datasets

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