Increased theta band EEG power in sickle cell disease patients.

ABSTRACT:

Objective

Pain is a major issue in the care of patients with sickle cell disease (SCD). The mechanisms behind pain and the best way to treat it are not well understood. We studied how electroencephalography (EEG) is altered in SCD patients.

Methods

We recruited 20 SCD patients and compared their resting state EEG to that of 14 healthy controls. EEG power was found across frequency bands using Welch's method. Electrophysiological source imaging was assessed for each frequency band using the eLORETA algorithm.

Results

SCD patients had increased theta power and decreased beta2 power compared to controls. Source localization revealed that areas of greater theta band activity were in areas related to pain processing. Imaging parameters were significantly correlated to emer

SUBMITTER: Case M 

PROVIDER: S-EPMC5749555 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature