GSMC: Combining Parallel Gibbs Sampling with Maximal Cliques for Hunting DNA Motif.

ABSTRACT: Regulatory elements are responsible for regulating gene transcription. Therefore, identification of these elements is a tremendous challenge in the field of gene expression. Transcription factors (TFs) play a key role in gene regulation by binding to target promoter sequences. A set of conserved sequence patterns with a highly similar structure that is bound by a TF is called a motif. Motif discovery has been a difficult problem over the past decades. Meanwhile, it is a foundation stone in meeting this challenge. Recent advances in obtaining genomic sequences and high-throughput gene expression analysis techniques have enabled the rapid development of computational methods for motif discovery. As a result, a large number of motif-finding algorithms aiming at various motif models have sprun

SUBMITTER: Pei C 

PROVIDER: S-EPMC5749607 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature