Ontology highlight
ABSTRACT:
SUBMITTER: Silvin A
PROVIDER: S-EPMC5749640 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Science immunology 20170701 13
Dendritic cells (DCs) are critical for the launching of protective T cell immunity in response to viral infection. Viruses can directly infect DCs, thereby compromising their viability and suppressing their ability to activate immune responses. How DC function is maintained in light of this paradox is not understood. By analyzing the susceptibility of primary human DC subsets to viral infections, we report that CD141<sup>+</sup> DCs have an innate resistance to infection by a broad range of enve ...[more]