Neoadjuvant radiochemotherapy decreases the total amount of tumor infiltrating lymphocytes, but increases the number of CD8+/Granzyme B+ (GrzB) cytotoxic T-cells in rectal cancer.

ABSTRACT: Although neoadjuvant radiochemotherapy (nRCTx) is an established oncological treatment in patients with advanced rectal cancer, little is known about its effects on the tumor microenvironment. Quantity and composition of tumor infiltrating lymphocytes (TILs) are known to influence patients' prognosis but nRCTx-induced modifications are still unclear. We determined the composition of the immune cell infiltrate in rectal cancer after nRCTx and its influence on tumor regression, local recurrence rate and survival. We investigated density and composition of tumor infiltrating CD3⁺ and CD8⁺ T-cells and the quantity and ratio of CD8⁺/GrzB⁺ T-cells to CD8⁺ T-cells in 130 rectal cancers after nRCTx compared to a cohort of 30 primarily resected

SUBMITTER: Jarosch A 

PROVIDER: S-EPMC5749657 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature