Citrullinated α-enolase is an effective target for anti-cancer immunity.

ABSTRACT: Targeting post-translationally modified epitopes may provide a new strategy for generating tumor specific immune responses. Citrullination is the post-translational modification of arginine to citrulline catalyzed by peptidylarginine deaminase (PAD) enzymes. Presentation of citrullinated peptides on MHC-II has been associated with autophagy. Tumors upregulate autophagy and present citrullinated peptides in response to stresses including nutrient deprivation, oxygen deprivation, redox stress and DNA damage, making them good targets for immune attack. The ubiquitous glycolytic enzyme α-enolase (ENO1) is often citrullinated and degraded during autophagy. Immunization of mice with two citrullinated ENO1 peptides (ENO1 241-260cit₂₅₃ or 11-25cit₁₅) induced strong Th1 respon

SUBMITTER: Cook K 

PROVIDER: S-EPMC5749660 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature