Blockade of PD-1 effectively inhibits in vivo malignant transformation of oral mucosa.

ABSTRACT: Curbing PD-1 immunosuppressive signaling represents an effective immune awakening or immune-reactivation approach for tumor eradication for many cancers. Yet, the potential involvement of this critical PD-1 immunosuppressive signaling in de novo malignant transformation of epithelial cells to pre-cancerous or cancerous lesions is largely unknown. In this study, we demonstrate that PD-1 signaling is critically involved in de novo malignant transformation of oral mucosa upon carcinogen exposure in vivo. Our findings revealed that 4NQO-treated mice had almost double the numbers of PD-1-positive CD4⁺ cells and PD-1-positive CD8⁺ cells in peripheral blood lymphocytes as well as elevated PD-1 expression in tumor infiltrating lymphocytes (when compared t

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5749661 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature