FLP-1 neuropeptides modulate sensory and motor circuits in the nematode Caenorhabditis elegans.

ABSTRACT: Parasitic nematodes infect over one quarter of the population worldwide, causing morbidity in over one billion people. Current anthelmintic drugs are beginning to lose effectiveness due to the presence of resistant strains. We are interested in the role of neuropeptides, which regulate behaviors in all organisms, as another possible target for anthelmintic drugs. FMRFamide-related peptides (FaRPs) are a family of neuropeptides that are conserved throughout the animal kingdom. In particular, nematodes contain the largest family of FaRPs identified thus far and many of these FaRPs are identical among different nematode species; FaRPs in nematodes are collectively referred to as FLPs (FMRFamide-like peptides). However, little is known about the function of these FLPs. We are using the non-par

SUBMITTER: Buntschuh I 

PROVIDER: S-EPMC5749679 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature