Whole genome resequencing identifies the CPQ gene as a determinant of ascites syndrome in broilers.

ABSTRACT:

Background

Ascites syndrome is the most severe manifestation of pulmonary hypertension in fast-growing broilers. The disease can be attributed to increased body weights of birds, where the higher metabolic load is not matched by sufficient oxygen supply to the cells and tissues. Although there are environmental components, the disease exhibits moderate to high heritability. The current study uses high throughput whole genome resequencing (WGR) to identify genes and chromosomal regions associated with ascites.

Results

The WGR data identified the CPQ gene on chromosome 2. The association was confirmed by genotyping a large collection of DNAs from phenotyped birds from three distinct broiler lines using SNPs in intron 6 and exon 8 of the CPQ gene. By combining the genotype data

SUBMITTER: Dey S 

PROVIDER: S-EPMC5749702 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature