A meta-analysis of associations of LEPR Q223R and K109R polymorphisms with Type 2 diabetes risk.

ABSTRACT:

Background

Leptin receptor (LEPR) plays a pivotal role in the control of body weight, energy metabolism, and insulin sensitivity. Various genetic association studies were performed to evaluate associations of LEPR genetic variants with type 2 diabetes (T2D) susceptibility.

Methods

A comprehensive search was conducted to identify all eligible case-control studies for examining the associations of LEPR single nucleotide polymorphisms (SNPs) Q223R (rs1137101) and K109R (rs1137100) with T2D risk. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were used to measure the magnitudes of association.

Results

For Q223R, 13 studies (11 articles) consisting of a total of 4030 cases and 2844 controls, and for K109R 7 studies (7 articles) consisting of 3319 cases a

SUBMITTER: Yang Y 

PROVIDER: S-EPMC5749718 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature