Computer-analyzed facial expression as a surrogate marker for autism spectrum social core symptoms.

ABSTRACT: To develop novel interventions for autism spectrum disorder (ASD) core symptoms, valid, reliable, and sensitive longitudinal outcome measures are required for detecting symptom change over time. Here, we tested whether a computerized analysis of quantitative facial expression measures could act as a marker for core ASD social symptoms. Facial expression intensity values during a semi-structured socially interactive situation extracted from the Autism Diagnostic Observation Schedule (ADOS) were quantified by dedicated software in 18 high-functioning adult males with ASD. Controls were 17 age-, gender-, parental socioeconomic background-, and intellectual level-matched typically developing (TD) individuals. Statistical analyses determined whether values representing the strength and variabil

SUBMITTER: Owada K 

PROVIDER: S-EPMC5749804 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature