Elucidation of the mechanism behind the potentiating activity of baicalin against Burkholderia cenocepacia biofilms.

ABSTRACT: Reduced antimicrobial susceptibility due to resistance and tolerance has become a serious threat to human health. An approach to overcome this reduced susceptibility is the use of antibiotic adjuvants, also known as potentiators. These are compounds that have little or no antibacterial effect on their own but increase the susceptibility of bacterial cells towards antimicrobial agents. Baicalin hydrate, previously described as a quorum sensing inhibitor, is such a potentiator that increases the susceptibility of Burkholderia cenocepacia J2315 biofilms towards tobramycin. The goal of the present study is to elucidate the molecular mechanisms behind the potentiating activity of baicalin hydrate and related flavonoids. We first determined the effect of multiple flavonoids on susceptibility of

SUBMITTER: Slachmuylders L 

PROVIDER: S-EPMC5749847 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature