Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation.

ABSTRACT:

Aims

Medical treatment of arterial thrombosis is mainly directed against platelets and coagulation factors, and can lead to bleeding complications. Novel antithrombotic therapies targeting immune cells and neutrophil extracellular traps (NETs) are currently being investigated in animals. We addressed whether immune cell composition of arterial thrombi induced in mouse models of thrombosis resemble those of human patients with acute myocardial infarction (AMI).

Methods and results

In a prospective cohort study of patients suffering from AMI, 81 human arterial thrombi were harvested during percutaneous coronary intervention and subjected to detailed histological analysis. In mice, arterial thrombi were induced using two distinct experimental models, ferric chloride (FeCl3) and

SUBMITTER: Novotny J 

PROVIDER: S-EPMC5749862 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature