Numerical simulations of targeted delivery of magnetic drug aerosols in the human upper and central respiratory system: a validation study.

ABSTRACT: In the present study, we investigate the concept of the targeted delivery of pharmaceutical drug aerosols in an anatomically realistic geometry of the human upper and central respiratory system. The geometry considered extends from the mouth inlet to the eighth generation of the bronchial bifurcations and is identical to the phantom model used in the experimental studies of Banko et al. (2015 Exp. Fluids56, 1-12 (doi:10.1007/s00348-015-1966-y)). In our computer simulations, we combine the transitional Reynolds-averaged Navier-Stokes (RANS) and the wall-resolved large eddy simulation (LES) methods for the air phase with the Lagrangian approach for the particulate (aerosol) phase. We validated simulations against recently obtained magnetic resonance velocimetry measureme

SUBMITTER: Kenjeres S 

PROVIDER: S-EPMC5749997 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature