Association of attention-deficit/hyperactivity disorder with a candidate region for reading disabilities on chromosome 6p.

ABSTRACT:

Background

Reading disabilities (RD) and attention-deficit hyperactivity/disorder (ADHD) are two common childhood disorders that co-occur by chance more often than expected. Twin studies and overlapping genetic linkage findings indicate that shared genetic factors partially contribute to this comorbidity. Linkage of ADHD to 6p, an identified RD candidate locus, has previously been reported, suggesting the possibility of a pleiotropic gene at this locus. RD has been previously associated with five genes in the region, particularly DCDC2 and KIAA0319.

Methods

To test whether these genes also contribute to ADHD, we investigated markers previously associated with RD for association with ADHD and ADHD symptoms in a sample of families with ADHD (n = 264). Markers were located in t

SUBMITTER: Couto JM 

PROVIDER: S-EPMC5750043 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature