Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure?

ABSTRACT:

Background

Externalizing disorders are heritable precursors to alcohol dependence, common in children of alcoholics (COA), and in children with prenatal alcohol exposure (PAE). Pregnancies involving alcohol exposure sufficient to affect the fetus may involve women with genetic risk for alcohol dependence. We hypothesized that known PAE will increase the odds of having an externalizing disorder compared to COA.

Methods

The odds ratios of 3 externalizing disorders (attention-deficit hyperactivity disorder [ADHD], conduct disorder [CD], and oppositional defiant disorder [ODD]) were obtained for 2 domains: (i) PAE and (ii) COA, by estimating the logged odds ratio (LOR) for each study. Permutation tests were implemented to compare LORs for PAE versus COA studies within each disor

SUBMITTER: Wetherill L 

PROVIDER: S-EPMC5750073 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature