Pilot trial of CRLX101 in patients with advanced, chemotherapy-refractory gastroesophageal cancer.

ABSTRACT:

Background

CRLX101 is an investigational nanoparticle-drug conjugate with a camptothecin payload. Preclinical evidence indicated preferential uptake in tumors, and tumor xenograft models demonstrate superiority of CRLX101 over irinotecan. A pilot trial was conducted at recommended phase 2 dosing (RP2D) using the bimonthly schedule to assess preferential uptake of CRLX101 in tumor vs. adjacent normal tissue in endoscopically accessible tumors in chemotherapy-refractory gastroesophageal cancer. Results from the biopsies were previously reported and herein we present the clinical outcomes.

Methods

Patients initiated CRLX101 dosed at RP2D (15 mg/m²) on days 1 and 15 of a 28-day cycle. Detection of preferential CRLX101 tumor uptake was the primary endpoint and o

SUBMITTER: Chao J 

PROVIDER: S-EPMC5750185 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature