Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a Japanese population.

ABSTRACT: Genome-wide association studies have identified various genetic variants associated with complex disorders. However, these studies have commonly been conducted in a cross-sectional manner. Therefore, we performed a longitudinal exome-wide association study (EWAS) in a Japanese cohort. We aimed to identify genetic variants that confer susceptibility to hypertension using ~244 000 single-nucleotide variants (SNVs) and physiological data from 6026 Japanese individuals who underwent annual health check-ups for several years. After quality control, the association of hypertension with SNVs was tested using a generalized estimating equation model. Finally, our longitudinal EWAS detected seven hypertension-related SNVs that passed strict criteria. Among these variants, six SNVs were densely locat

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC5750474 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature