Pseudoreference Regions for Glial Imaging with ¹¹C-PBR28: Investigation in 2 Clinical Cohorts.

ABSTRACT: The translocator protein (TSPO) is a commonly used imaging target to investigate neuroinflammation. Although TSPO imaging demonstrates great promise, its signal exhibits substantial interindividual variability, which needs to be accounted for to uncover group effects that are truly reflective of neuroimmune activation. Recent evidence suggests that relative metrics computed using pseudoreference approaches can minimize within-group variability and increase sensitivity to detect physiologically meaningful group differences. Here, we evaluated various ratio approaches for TSPO imaging and compared them with standard kinetic modeling techniques, analyzing 2 different disease cohorts. Patients with chronic low back pain (cLBP) or amyotrophic lateral sclerosis (ALS) and matching healthy control

SUBMITTER: Albrecht DS 

PROVIDER: S-EPMC5750517 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature