Noninvasive ⁸⁹Zr-Transferrin PET Shows Improved Tumor Targeting Compared with ¹⁸F-FDG PET in MYC-Overexpressing Human Triple-Negative Breast Cancer.

ABSTRACT: The current standard for breast PET imaging is ¹⁸F-FDG. The heterogeneity of ¹⁸F-FDG uptake in breast cancer limits its utility, varying greatly among receptor status, histopathologic subtypes, and proliferation markers. ¹⁸F-FDG PET often exhibits nonspecific internalization and low specificity and sensitivity, especially with tumors smaller than 1 cm³ MYC is a protein involved in oncogenesis and is overexpressed in triple-negative breast cancer (TNBC). Increased surface expression of transferrin receptor (TfR) is a downstream event of MYC upregulation and has been validated as a clinically relevant target for molecular imaging. Transferrin labeled with ⁸⁹Zr has successfully identified MYC status in many cancer subtypes preclinically a

SUBMITTER: Henry KE 

PROVIDER: S-EPMC5750524 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature