Prebiotic Oligosaccharides Potentiate Host Protective Responses against L. Monocytogenes Infection.

ABSTRACT: Prebiotic oligosaccharides are used to modulate enteric pathogens and reduce pathogen shedding. The interactions with prebiotics that alter Listeria monocytogenes infection are not yet clearly delineated. L. monocytogenes cellular invasion requires a concerted manipulation of host epithelial cell membrane receptors to initiate internalization and infection often via receptor glycosylation. Bacterial interactions with host glycans are intimately involved in modulating cellular responses through signaling cascades at the membrane and in intracellular compartments. Characterizing the mechanisms underpinning these modulations is essential for predictive use of dietary prebiotics to diminish pathogen association. We demonstrated that human milk oligosaccharide (HMO) pretreatment o

SUBMITTER: Chen P 

PROVIDER: S-EPMC5750592 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature