A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes.

ABSTRACT: Effective malaria control and elimination in hyperendemic areas of the world will require treatment of the Plasmodium falciparum (Pf) blood stage that causes disease as well as the gametocyte stage that is required for transmission from humans to the mosquito vector. Most currently used therapies do not kill gametocytes, a highly specialized, non-replicating sexual parasite stage. Further confounding next generation drug development against Pf is the unknown metabolic state of the gametocyte and the lack of known biochemical activity for most parasite gene products in general. Here, we take a systematic activity-based proteomics approach to survey the activity of the large and druggable ATPase family in replicating blood stage asexual parasites and transmissible, non-r

SUBMITTER: Ortega C 

PROVIDER: S-EPMC5750841 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature