ProphTools: general prioritization tools for heterogeneous biological networks.

ABSTRACT:

Background

Networks have been proven effective representations for the analysis of biological data. As such, there exist multiple methods to extract knowledge from biological networks. However, these approaches usually limit their scope to a single biological entity type of interest or they lack the flexibility to analyze user-defined data.

Results

We developed ProphTools, a flexible open-source command-line tool that performs prioritization on a heterogeneous network. ProphTools prioritization combines a Flow Propagation algorithm similar to a Random Walk with Restarts and a weighted propagation method. A flexible model for the representation of a heterogeneous network allows the user to define a prioritization problem involving an arbitrary number of entity types and their

SUBMITTER: Navarro C 

PROVIDER: S-EPMC5751048 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature