Translational Aspects of Sphingolipid Metabolism in Renal Disorders.

ABSTRACT: Sphingolipids, long thought to be passive components of biological membranes with merely a structural role, have proved throughout the past decade to be major players in the pathogenesis of many human diseases. The study and characterization of several genetic disorders like Fabry's and Tay Sachs, where sphingolipid metabolism is disrupted, leading to a systemic array of clinical symptoms, have indeed helped elucidate and appreciate the importance of sphingolipids and their metabolites as active signaling molecules. In addition to being involved in dynamic cellular processes like apoptosis, senescence and differentiation, sphingolipids are implicated in critical physiological functions such as immune responses and pathophysiological conditions like inflammation and insulin resistance. Inte

SUBMITTER: Abou Daher A 

PROVIDER: S-EPMC5751131 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature