Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism.

ABSTRACT:

Purpose

Age-related macular degeneration (AMD) is a devastating disease characterized by central vision impairment in individuals with advanced age. Neovascular AMD is a form of end-stage disease in which choroidal vessel outgrowth occurs beneath the retina. While many hypotheses have been raised as to what triggers the formation of pathological choroidal neovascular membranes, the exact mechanism for their initiation remains unresolved. Polymorphisms in the FLT1 gene have previously been associated with neovascular AMD risk, including the rs9943922 single nucleotide polymorphism (SNP). Here, we aimed to determine the association between the high-risk FLT1 genotype and FLT1 protein levels in human retina or retinal pigment epithelium (RPE)/choroid tissue.

Methods

Retina and

SUBMITTER: Chirco KR 

PROVIDER: S-EPMC5751420 | biostudies-literature | 2018 Jan-Feb

REPOSITORIES: biostudies-literature