Persistent accumulation of gut macrophages with impaired phagocytic function correlates with SIV disease progression in macaques.

ABSTRACT: The contribution of macrophages in the gastrointestinal tract to disease control or progression in HIV infection remains unclear. To address this question, we analyzed CD163⁺ macrophages in ileum and mesenteric lymph nodes (LN) from SIV-infected rhesus macaques with dichotomous expression of controlling MHC class I alleles predicted to be SIV controllers or progressors. Infection induced accumulation of macrophages into gut mucosa in the acute phase that persisted in progressors but was resolved in controllers. In contrast, macrophage recruitment to mesenteric LNs occurred only transiently in acute infection irrespective of disease outcome. Persistent gut macrophage accumulation was associated with CD163 expression on α4β7⁺ CD16⁺ blood monocytes and correla

SUBMITTER: Swan ZD 

PROVIDER: S-EPMC5751436 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature