Refine gene functional similarity network based on interaction networks.

ABSTRACT: BACKGROUND:In recent years, biological interaction networks have become the basis of some essential study and achieved success in many applications. Some typical networks such as protein-protein interaction networks have already been investigated systematically. However, little work has been available for the construction of gene functional similarity networks so far. In this research, we will try to build a high reliable gene functional similarity network to promote its further application. RESULTS:Here, we propose a novel method to construct and refine the gene functional similarity network. It mainly contains three steps. First, we establish an integrated gene functional similarity networks based on different functional similarity calculation methods. Then, we construct a referenced gen

SUBMITTER: Tian Z 

PROVIDER: S-EPMC5751769 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature