A database of human genes and a gene network involved in response to tick-borne encephalitis virus infection.

ABSTRACT:

Background

Tick-borne encephalitis is caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). TBEV infection can lead to a variety of clinical manifestations ranging from slight fever to severe neurological illness. Very little is known about genetic factors predisposing to severe forms of disease caused by TBEV. The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins.

Results

Based on manual review and curation of scientific publications a catalog comprising 140 human genes involved in response to TBEV infection was developed. To provide acce

SUBMITTER: Ignatieva EV 

PROVIDER: S-EPMC5751789 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature