Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death worldwide, for which smoking is considered as the primary risk factor. The present study was conducted to determine whether genetic alterations induced by radon exposure are associated with the susceptible risk of lung cancer in never smokers.

Methods

To accurately identify mutations within individual tumors, next generation sequencing was conduct for 19 pairs of lung cancer tissue. The associations of germline and somatic variations with radon exposure were visualized using OncoPrint and heatmap graphs. Bioinformatic analysis was performed using various tools.

Results

Alterations in several genes were implicated in lung cancer resulting from exposure to radon indoors, namely those in epidermal growth

SUBMITTER: Choi JR 

PROVIDER: S-EPMC5751841 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature