Cyclic versus Noncyclic Chelating Scaffold for ⁸⁹Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression.

ABSTRACT: Zirconium-89 is an emerging radionuclide for positron emission tomography (PET) especially for biomolecules with slow pharmacokinetics as due to its longer half-life, in comparison to fluorine-18 and gallium-68, imaging at late time points is feasible. Desferrioxamine B (DFO), a linear bifunctional chelator (BFC) is mostly used for this radionuclide so far but shows limitations regarding stability. Our group recently reported on fusarinine C (FSC) with similar zirconium-89 complexing properties but potentially higher stability related to its cyclic structure. This study was designed to compare FSC and DFO head-to-head as bifunctional chelators for ⁸⁹Zr-radiolabeled EGFR-targeting ZEGFR:2377 affibody bioconjugates.

Fsc-zegfr

2377 and DFO-ZEGFR:2377 were evaluated regarding

SUBMITTER: Summer D 

PROVIDER: S-EPMC5751887 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature