Therapeutic drug repositioning using personalized proteomics of liquid biopsies.

ABSTRACT:

Background

In patients with limited response to conventional therapeutics, repositioning of already approved drugs can bring new, more effective options. Current drug repositioning methods, however, frequently rely on retrospective computational analyses and genetic testing - time consuming methods that delay application of repositioned drugs. Here, we show how proteomic analysis of liquid biopsies successfully guided treatment of neovascular inflammatory vitreoretinopathy (NIV), an inherited autoinflammatory disease with otherwise poor clinical outcomes.

Methods

Vitreous biopsies from NIV patients were profiled by an antibody array for expression of 200 cytokine-signaling proteins. Non-NIV controls were compared with NIV samples from various stages of disease progression. P

SUBMITTER: Velez G 

PROVIDER: S-EPMC5752263 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature