Serum microRNA signatures and metabolomics have high diagnostic value in hepatocellular carcinoma.

ABSTRACT:

Background

Many new diagnostic biomarkers have been developed for hepatocellular carcinoma (HCC). We selected two methods with high diagnostic value, the detection of serum microRNAs and metabolomics based on gas chromatography/mass spectrometry (GC/MS), and attempted to establish appropriate models.

Methods

We reviewed the diagnostic efficiencies of all microRNAs identified by previous diagnostic tests. Then we chose appropriate microRNAs to validate the diagnostic efficiencies, and determined the optimal combination. We included 66 patients with HCC and 82 healthy controls (HCs) and detected the expression of the microRNAs. GC/MS analysis was performed, and we used three multivariate statistical methods to establish diagnostic models. The concentration of alpha feto-protei

SUBMITTER: Liu HN 

PROVIDER: S-EPMC5752483 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature