Tumour-microenvironmental blood flow determines a metabolomic signature identifying lysophospholipids and resolvin D as biomarkers in endometrial cancer patients.

ABSTRACT:

Purpose

We aimed to study the potential influence of tumour blood flow -obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)- in the metabolomic profiles of endometrial tumours.

Methods

Liquid chromatography coupled to mass spectrometry established the metabolomic profile of endometrial cancer lesions exhibiting high (n=12) or low (n=14) tumour blood flow at DCE-MRI. Univariate and multivariate statistics (ortho-PLS-DA, a random forest (RF) classifier and hierarchical clustering) and receiver operating characteristic (ROC) curves were used to establish a panel for potentially discriminating tumours with high versus low blood flow.

Results

Tumour blood flow is associated with specific metabolomic signatures. Ortho-PLS-DA and RF classifier result

SUBMITTER: Eritja N 

PROVIDER: S-EPMC5752500 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature