Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.

ABSTRACT: Bipolar disorder is characterized by recurring episodes of depression and mania. Defining differences in brain function during these states is an important goal of bipolar disorder research. However, few imaging studies have directly compared brain activity between bipolar mood states. Herein, we compare functional magnetic resonance imaging (fMRI) responses during a flashing checkerboard stimulus between bipolar participants across mood states (euthymia, depression, and mania) in order to identify functional differences between these states. 40 participants with bipolar I disorder and 33 healthy controls underwent fMRI during the presentation of the stimulus. A total of 23 euthymic-state, 16 manic-state, 15 depressed-state, and 32 healthy control imaging sessions were analyzed in order to

SUBMITTER: Shaffer JJ 

PROVIDER: S-EPMC5752628 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature