MiR-98 inhibits malignant progression via targeting MTDH in squamous cell carcinoma of the head and neck.

ABSTRACT:

Purpose

MicroRNAs function through regulating specific target mRNA expression and then participate in the development and progression of diverse human cancers. MiR-98 shows aberrant expression and dysfunction in tumors. However, its clinical significance and exact role in squamous cell carcinoma of the head and neck (SCCHN) remain elusive.

Methods

MiR-98 expression was examined by qRT-PCR and correlated with clinicopathological variables and prognosis in SCCHN patients. Effects of miR-98 on epithelial-mesenchymal transition (EMT) and the malignant phenotypes of SCCHN were studied. Finally, the role of target gene metadherin (MTDH) in miR-98 mediated effects were assayed.

Results

Our results demonstrated that miR-98, as an endogenous inhibitor of MTDH via directly bind

SUBMITTER: Tan H 

PROVIDER: S-EPMC5752695 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature