Estrogen receptor α gene polymorphism and vascular complications in girls with type 1 diabetes mellitus.

ABSTRACT: The effect of estrogens is mediated by activation of estrogen receptors (ERs). Because ER-α gene polymorphisms may exert different effects in childhood, we analyzed the associations between the IVS1 -397T>C (PvuII) polymorphism and systemic inflammatory state, proangiogenic factors, frequency of monocyte subsets, lipid profile, blood pressure, and vascular complications in girls with type 1 diabetes mellitus (DM1). We examined 180 young girls with DM1 and 120 healthy age-matched controls. The analysis concerned PvuII polymorphism of the ER-α gene as well as the levels of serum inflammatory markers (CRP, IL-6, TNF-α), proangiogenic factors (VEGF, angiogenin), 17β-estradiol, values of monocyte subsets (CD14⁺⁺CD16^- and CD14⁺CD16⁺), lipid profile, an

SUBMITTER: Slominski B 

PROVIDER: S-EPMC5752735 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature