Qiliqiangxin attenuates isoproterenol-induced cardiac remodeling in mice.

ABSTRACT:

Background

To further explore the role of PPARγ in QL treatment, ISO-induced mice model and following methods were established.

Methods

Cardiac remodeling on mice model was induced by isoproterenol (ISO) infusion or saline infusion as control for two weeks then divided into 4 groups, after that divided in 5 different treatment methods to investigate the role of PPARγ in QL therapy. Echocardiography and Masson's trichrome staining were respectively used to determine cardiac function and fibrosis. Immunoblotting was applied to evaluate the expression levels of proliferator-activated receptor-γ (PPARγ), Bax, Bcl, phospho-Akt (Ser473), Akt, phospho-P38 and P38, phosphor-ERK and ERK.

Results

QL treatment improved left ventricular function, decreased apoptosis, and prevente

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5752908 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature