The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers.

ABSTRACT: The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the corresponding syn-diastereomer. Both targets were synthesised using an epoxide opening strategy.

SUBMITTER: Szpera R 

PROVIDER: S-EPMC5753060 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature