ECOdrug: a database connecting drugs and conservation of their targets across species.

ABSTRACT: Pharmaceuticals are designed to interact with specific molecular targets in humans and these targets generally have orthologs in other species. This provides opportunities for the drug discovery community to use alternative model species for drug development. It also means, however, there is potential for mode of action related effects in non-target wildlife species as many pharmaceuticals reach the environment through patient use and manufacturing wastes. Acquiring insight in drug target ortholog predictions across species and taxonomic groups has proven difficult because of the lack of an optimal strategy and because necessary information is spread across multiple and diverse sources and platforms. We introduce a new research platform tool, ECOdrug, that reliably connects drugs to their

SUBMITTER: Verbruggen B 

PROVIDER: S-EPMC5753218 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature