The online Tabloid Proteome: an annotated database of protein associations.

ABSTRACT: A complete knowledge of the proteome can only be attained by determining the associations between proteins, along with the nature of these associations (e.g. physical contact in protein-protein interactions, participation in complex formation or different roles in the same pathway). Despite extensive efforts in elucidating direct protein interactions, our knowledge on the complete spectrum of protein associations remains limited. We therefore developed a new approach that detects protein associations from identifications obtained after re-processing of large-scale, public mass spectrometry-based proteomics data. Our approach infers protein association based on the co-occurrence of proteins across many different proteomics experiments, and provides information that is almost completely comp

SUBMITTER: Gupta S 

PROVIDER: S-EPMC5753264 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature