Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD.

ABSTRACT:

Background and objectives

Metabolic acidosis is common in patients with CKD and has significant adverse effects on kidney, muscle, and bone. We tested the efficacy and safety of TRC101, a novel, sodium-free, nonabsorbed hydrochloric acid binder, to increase serum bicarbonate in patients with CKD and metabolic acidosis.

Design, setting, participants, & measurements

One hundred thirty-five patients were enrolled in this randomized, double-blind, placebo-controlled, multicenter, in-unit study (designated the TRCA-101 Study). Patients had a mean baseline eGFR of 35 ml/min per 1.73 m², a mean baseline serum bicarbonate of 17.7 mEq/L, and comorbidities, including hypertension (93%), diabetes (70%), and heart failure (21%). Patients ate a controlled diet and were treated

SUBMITTER: Bushinsky DA 

PROVIDER: S-EPMC5753317 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature