ASpedia: a comprehensive encyclopedia of human alternative splicing.

ABSTRACT: Alternative splicing confers the human genome complexity by increasing the diversity of expressed mRNAs. Hundreds or thousands of splicing regions have been identified through differential alternative splicing analysis of high-throughput datasets. However, it is hard to explain the functional impact of each splicing event. Protein domain formation and nonsense-mediated decay are considered the main functional features of splicing. However, other functional features such as miRNA target sites, phosphorylation sites and single-nucleotide variations are directly affected by alternative splicing and affect downstream function. Hence, we established ASpedia: a comprehensive database for human alternative splicing annotation, which encompasses a range of functions, from genomic annotation to iso

SUBMITTER: Hyung D 

PROVIDER: S-EPMC5753336 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature