OverGeneDB: a database of 5' end protein coding overlapping genes in human and mouse genomes.

ABSTRACT: Gene overlap plays various regulatory functions on transcriptional and post-transcriptional levels. Most current studies focus on protein-coding genes overlapping with non-protein-coding counterparts, the so called natural antisense transcripts. Considerably less is known about the role of gene overlap in the case of two protein-coding genes. Here, we provide OverGeneDB, a database of human and mouse 5' end protein-coding overlapping genes. The database contains 582 human and 113 mouse gene pairs that are transcribed using overlapping promoters in at least one analyzed library. Gene pairs were identified based on the analysis of the transcription start site (TSS) coordinates in 73 human and 10 mouse organs, tissues and cell lines. Beside TSS data, resources for 26 human lung adenocarcinoma

SUBMITTER: Rosikiewicz W 

PROVIDER: S-EPMC5753363 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature