SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial.

ABSTRACT:

Background and aims

Sodium tissue content by ²³Na magnetic resonance imaging (Na-MRI) has been validated in experimental and human studies. SGLT-2 inhibition blocks the reabsorption of glucose and of sodium in the proximal tubular cells in a 1:1 fashion. We hypothesized that SGLT-2 inhibition in patients with type 2 diabetes characterized by sodium retention leads to decreased tissue sodium content due to its pharmacological action.

Materials and methods

In a prospective double blind, placebo controlled, cross-over trial 59 patients (61 ± 7.6 years) with type 2 diabetes were randomized to either dapagliflozin 10 mg or placebo once daily for 6 weeks each. In addition to metabolic parameters and ambulatory blood pressure (BP) we analysed the sodium content in the sk

SUBMITTER: Karg MV 

PROVIDER: S-EPMC5753452 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature