The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC).

ABSTRACT:

Background

Triple Negative Breast Cancers (TNBCs) lack the appropriate targets for currently used breast cancer therapies, conferring an aggressive phenotype, more frequent relapse and poorer survival rates. The biological heterogeneity of TNBC complicates the clinical treatment further. We have explored and compared the biological pathways in TNBC and other subtypes of breast cancers, using an in silico approach and the hypothesis that two opposing effects (Yin and Yang) pathways in cancer cells determine the fate of cancer cells. Identifying breast subgroup specific components of these opposing pathways may aid in selecting potential therapeutic targets as well as further classifying the heterogeneous TNBC subtype.

Methods

Gene expression and patient clinical data from The

SUBMITTER: Narrandes S 

PROVIDER: S-EPMC5753474 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature